3AA-22.9. Summary of Modification Nomenclature

This version of 3AA-22.9 does not use the HTML table format.

The application of the principles of 3AA-22 is illustrated in Table 6.

Table 6. Application of the methods of modifying named peptides (Note i)

 
 Section  Operation  Short name                 Structure  

22.1 Replacement [Phe⁴]iupaciubin

22.2a Extension (N-terminal) Arg-iupaciubin

22.2b Extension (C-terminal) Iupaciubinyl-Met Ala-Lys-Glu-Tyr-Leu-Met

22.3 Insertion Endo-Thr^2a-iupaciubin

22.4 Removal Des-Glu³-iupaciubin

22.5.1 Side-chain substitution on amino group N^ε2-Val-iupaciubin

22.5.2 Side-chain substitution on carboxyl group C^δ3-Iupaciubinyl-Val

22.6 Partial sequence Iupaciubin-(2-4)-peptide Lys-Glu-Tyr

22.7 Reversal of sequence retro-Iupaciubin Leu-Tyr-Glu-Lys-Ala

22.7 Enantiomer ent-Iupaciubin D-Ala-D-Lys-D-Glu-D-Tyr-D-Leu

22.8 Replacement of CO-NH of peptide bond [³[psi]⁴,CH₂-S]iupaciubin Ala-Lys-Glu-[psi](CH₂-S)-Tyr-Leu

Addendum 3 Partial hydrolysis of a peptide [seco-3/4]oxytocin

Note (i) Entries in this table cannot alined in columns. Each row contains the Section it refers to, The Operation, Short Name and Structure in that order.

* Square brackets are required to indicate replacement, but are not used for most other modifications.